Pii: S0378-5173(01)00746-3
نویسنده
چکیده
Exposure of a drug to irradiation can influence the stability of the formulation, leading to changes in the physicochemical properties of the product. The influence of excipients of frequently used stabilizers is often difficult to predict and, therefore, stability testing of the final preparation is important. The selection of a protective packaging must be based on knowledge about the wavelength causing the instability. Details on drug photoreactivity will also be helpful in order to minimize side-effects and/or optimize drug targeting by developing photoresponsive drug delivery systems. This review focuses on practical problems related to formulation and stability testing of photolabile drugs. © 2001 Elsevier Science B.V. All rights reserved.
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Pii: S0378-5173(01)00804-3
Adsorption and controlled release of terbinafine hydrochloride (TER-HCl) to and from pH-sensitive poly(N-vinyl 2-pyrrolidone/itaconic acid) P(VP/IA) hydrogels were investigated. P(VP/IA) hydrogels were prepared by irradiating the ternary monomer mixtures of N-vinyl 2-pyrrolidone/itaconic acid/ethylene glycol dimethacrylate in aqueous solution by -rays at ambient temperature. Hydrogels containin...
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Noise-induced absolute instability is demonstrated in computer experiments with a one-dimensional reaction– diffusion system. This phenomenon may occur in spatially extended flow systems of different nature, when the parameters are chosen close to the point of transition from convective to absolute instability. © 2002 IMACS. Published by Elsevier Science B.V. All rights reserved.
متن کاملPii: S0378-5173(01)00606-8
The filtration behaviour of some clay–water dispersions was studied. Two Spanish fibrous phyllosilicates (sepiolite from Vicálvaro and palygorskite from Turón) and a commercial bentonite (Bentopharm©, UK) with similar sizes and different morphologies (fibrous and/or laminar) were selected as model clays. Sepiolite from Vicálvaro is an almost pure fibrous sample, Bentopharm© presents a high amou...
متن کاملPii: S0378-5173(02)00296-x
The tableting behavior of drugs can be affected by changes in the crystal habit. Different crystal habits of the common analgesic drugs ibuprofen and acetaminophen were prepared. Their tableting behavior was characterized. In the case of ibuprofen, a plate-shaped crystal was compared with the common needle-shaped form. In the case of acetaminophen, plate-shaped and prismatic crystals of two dif...
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